6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. (a) Which intermediate or intermediates in purine nucleotide biosynthesis would you

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6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases.

(a) Which intermediate or intermediates in purine nucleotide biosynthesis would you expect to accumulate in DON-treated cells?
(b) Which participants in pyrimidine synthesis?
(c) Speculate on the mechanism by which DON inhibits these enzymes.

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Biochemistry Concepts and Connections

ISBN: 978-0321839923

1st edition

Authors: Dean R. Appling, Spencer J. Anthony Cahill, Christopher K. Mathews

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Question Posted: Apr 21, 2016 04:22 AM

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6-Diazo-5-oxonorleucine (DON) irreversibly inhibits glutamine-dependent amidotransferases. (a) Which intermediate or intermediates in purine nucleotide biosynthesis would you

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CH2 CH2 H-C-NH COO

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a PRPP Formylglycinamide ribonucleotide intermediate 4 in IMP synthesis and XMPall subst...View the full answer

Biochemistry Concepts and Connections

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