A study concerning the plasma concentration of the drug ranitidine was reported in the Journal of Pharmaceutical Sciences. The drug was administered (coded I), and the plasma concentration of ranitidine was followed for 12 hours. The time to the first peak in concentration was called Tmax1.The same experiment was repeated 1 week later (coded II).Twelve subjects participated in the study. The correlation coefficient between Tmax1, I, and Tmax1, II, was reported to be 0.818. Use Table 11 in Appendix B to determine bounds on the p-value for the hypothesis test of Ho: r = 0 versus Ha: r ≠0.

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