Astridis, Inc. reported the following statement of cash flows in its 2016 annual report. Amounts are shown in thousands of dollars.

Required
Analyze Astridis's statement of cash flows by making at least two observations about each section of the statement.

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Astridis, Inc. Statement of Cash Flows For the Year Ending December 31 2016 2015 2014 Cash flows from operating activities Net income Adjustments to net income S(623,854) $(936,248) $746,837) Depreciation Provision for doubtful accounts Other non-cash items 00,670 05,749 98,555 4,011 9,082 7,613 81,206 460,013 177,536 Changes in operating assets and liabilities Receivables Inventory Prepaid expenses and other current assets Accounts payable and accrued expenses Other liabilities 42,600)(20,326) (45,705) 4,965 20,246 (6,329) 23,568 (61,698) (5,372) 66,169133,519 245,052 62,886 85,694 125,255 Net cash provided (used) by operating activities17 908) 245,930 153,834) Cash flows from investing activities Purchases of property and equipment Proceeds from sale of property and equipment Purchases of investments Sales of investments 90,708) (130,387) (51,367) 641 827 928 4,310) (105,279) (173,937) 255015 48,555 Net cash provided (used) by investing activities (54,186) 20,176 (175,821) Cash flows from financing activities Proceeds from issuance of long-term debt Repayment of debt Other 244,079 453,661 (625) 57,609) 75,879 Net cash provided (used) by financing activities248,351 25,787 471,931 76,257(199,967) 142,276 678,200 878,167 753,891 754,457$678,200 896,167 4,897 25,787 Change in cash Cash, beginning balance Cash,ending balance