Based on Sonderman and Abrahamson 1985 In treating a brain
Based on Sonderman and Abrahamson (1985). In treating a brain tumor with radiation, physicians want the maximum amount of radiation possible to bombard the tissue containing the tumors. The constraint is, however, that there is a maximum amount of radiation that normal tissue can handle without suffering tissue damage. Physicians must therefore decide how to aim the radiation so as to maximize the radiation that hits the tumor tissue subject to the constraint of not damaging the normal tissue. As a simple example of this situation, suppose there are six types of radiation beams (beams differ in where they are aimed and their intensity) that can be aimed at a tumor. The region containing the tumor has been divided into six regions: three regions contain tumors and three contain normal tissue. The amount of radiation delivered to each region by each type of beam is shown in the file S14_90.xlsx. If each region of normal tissue can handle at most 60 units of radiation, which beams should be used to maximize the total amount of radiation received by the tumors?

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