Question: Calculate the total number of germ line encoded VH and VL domains
Calculate the total number of germ-line-encoded VH and VL domains that can be constructed from the available Ig genes. Compare this to the numbers of germ-line-encoded Vβ and Vα domains of the TCR. How is diversity expanded in each pair of antigen-receptor proteins?
Answer to relevant QuestionsIn TCRs, diversity can be generated by recombination and reassortment events as in Igs. As is the case in Igs, additional diversity is generated with somatic events such as N nucleotide additions and reading of the D segment ...Although genetic recombination events are important for generating significant diversity in the antigen-binding site of Igs, post-recombination somatic events may be even more important in achieving overall Ig diversity. Do ...Identify six mechanisms responsible for antibiotic resistance. How are fluorescent antibodies used for the diagnosis of viral diseases? What advantages do fluorescent antibodies have over other tests for viral infections? Give examples of host- to- host transmission of disease via direct contact. Also give examples of indirect host- to- host transmission of disease via vector agents and fomites.
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