Comment on the fact that the reduction of pyruvate to lactate, catalyzed by lactate dehydrogenase, is strongly
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Comment on the fact that the reduction of pyruvate to lactate, catalyzed by lactate dehydrogenase, is strongly exergonic (recall this from Chapter 15), even though the standard free-energy change for the half reaction
Pyruvate + 2H+ + 2e ( Lactate
is positive (∆G°'= 36.2 kJ mol–1 = 8.8 kcal mol–1), indicating an endergonic reaction.
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