Describe what happens according to the “amyloid cascade hypothesis.”
Answer to relevant QuestionsA mutation that changes an alanine residue in a protein to an isoleucine leads to a loss of activity. Activity is regained when a further mutation at the same site changes the isoleucine to a glycine. Why? You are in the process of determining the ami-no acid sequence of a peptide. After trypsin digestion followed by the Edman degradation, you see the following peptide ...What are the main procedures involved in a western blot? Give an example of a scenario in which you could partially isolate a protein with differential centrifugation using only one spin. How does HPLC differ from ion-exchange chromatography?
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