Distinguish between the concerted and sequential models for the behavior of allosteric enzymes.
Answer to relevant QuestionsWhat are three advantages of using allosteric drugs as opposed to orthosteric ones? Explain why cleavage of the bond between arginine 15 and isoleucine 16 of chymotrypsinogen activates the zymogen. What would be the characteristics of a transition-state analog for the chymotrypsin reaction? What is the structure of ATCase? Which statements are consistent with the fluid-mosaic model of membranes? (a) All membrane proteins are bound to the interior of the membrane. (b) Both proteins and lipids undergo transverse (flip-flop) diffusion from the ...
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