Distinguish between the molecular mechanisms of competitive and noncompetitive inhibition.
Answer to relevant QuestionsWhere do lines intersect on a Lineweaver–Burk plot showing competitive inhibition? On a Lineweaver–Burk plot showing noncompetitive inhibition? Would nature rely on the same enzyme to catalyze a reaction either way (forward or backward) if the DG° were 20.8 kcal mol -1? If it were 25.3 kcal mol -1? What are three advantages of using allosteric drugs as opposed to orthosteric ones? Is the term KM used with allosteric enzymes? What about competitive and noncompetitive inhibition? Explain. Suggest a role for coenzymes based on reaction mechanisms.
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