Hodgkin's disease is a malignant, progressive, sometimes fatal disease of unknown cause characterized by enlargement of the lymph nodes, spleen, and liver. The following contingency table summarizes data collected during a study of 538 patients with Hodgkin's disease. The table cross-classifies the histological types of patients and their responses to treatment 3 months prior to the study.

At the 1% significance level, do the data provide sufficient evidence to conclude that histological type and treatment response are statistically dependent?

Transcribed Image Text:

Response Positive Partial None Total Lymphocyte 10 44 72 depletion Lymphocyte 12 104 58 266 12 96 98 126 538 18 predominance Mixed cellularity Nodular 154 54 16 314