In metabolism, glucose-6-phosphate (G6P) can be used for glycogen synthesis or for glycolysis, among other fates. What does it cost, in terms of ATP equivalents, to store G6P as glycogen, rather than to use it for energy in glycolysis? Hint: The branched structure of glycogen leads to 90% of glucose residues being released as glucose-1-phosphate and 10% as glucose.
Answer to relevant QuestionsDraw the structures of the activated carbon groups bound to thiamine pyrophosphate in three enzymes that contain this coenzyme. What are the major differences between the oxidations in the citric acid cycle that use NAD+ as an electron acceptor and the one that uses FAD? Using the information in Chapters 17–19, calculate the amount of ATP that can be produced from one molecule of lactose metabolized aerobically through glycolysis and the citric acid cycle. Which is more favorable energetically, the oxidation of succinate to fumarate by NAD+ or by FAD? Give the reason for your answer. Why is it difficult to determine an exact number for P/O ratios?
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