Many biochemical reactions are catalyzed by large protein molecules called enzymes. A typical mechanism for the conversion of a biochemical substrate (S) to product (P) catalyzed by an enzyme (E) involves the following steps:

The rate-determining step is the decomposition of the intermediate enzyme€“substrate complex (ES) to products (P). Under these conditions, show that the overall rate of product formation is

Where [E] T equals the total enzyme concentration: [E]T = [E] + [ES]

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