Many metabolic reactions are actually coupled reactions. A common coupled reaction is substrate phosphorylation by ATP. For example, the oxidation of glucose begins with its phosphorylation to glucose-6-phosphate (G6P).
(a) For the reaction

Calculate the ratio of [G6P]/[glucose][Pi] at equilibrium at 25°C.
(b) In muscle cells at 37°C, the steady-state ratio of [ATP]/[ADP] is 12. Assuming that glucose and G6P achieve equilibrium values in muscle, what is the ratio of [G6P] to [glucose]?

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Glucose Pglucose-6-phosphate H2O