Pentobarbital, marketed under the name Nembutal, is a barbiturate used in treating insomnia. It is synthesized in
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Pentobarbital, marketed under the name Nembutal, is a barbiturate used in treating insomnia. It is synthesized in three steps from diethyl malonate. Show how you would synthesize the dialkylated intermediate, and then propose a mechanism [or the reaction of that intermediate with urea to givepentobarbital.
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H. CO2Et CO2Et CO2Et H2N Na* "OEt NH2 СоДEt Н Diethyl malonate Pentobarbital (Nembutal) Dialkylated diethyl malonate
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