Refer to Exercise 18.13. Suppose the sleep durations for period 2 of sequence 1 were as follows: 8.5 7.6 8.5 8.3 7.2 7.0 6.4 6.1
In Exercise 18.13
An investigational drug product was studied under sleep laboratory conditions to determine its effect on duration of sleep. A group of 16 patients willing to participate in the study was randomly assigned to one of two drug sequences; 8 were to receive the investigational drug in ­period 1 and an identical- appearing placebo in period 2, and the remaining 8 patients were to ­receive the treatment in the reverse order.
a. Plot the study data for both sequences.
b. Does the design still seem to be appropriate? Is there a possible explanation for what happened?