# Question

Refer to Exercise 18.18. Run an analysis of variance for a three-period crossover design. Does your analysis confirm the intuition you expressed in Exercise 18.18? Use a 5.05.

In Exercise 18.18

Many of us have been exposed to advertising related to the “bioavailability” of generic and brand- name formulations of the same drug product. One way to compare the bioavailability of two formulations of a drug product is to compare areas under the concentration curve (AUC) for subjects treated with both formulations. For example, the shaded area in the figure represents the AUC for a patient treated with a single dose of a drug.

A three- period crossover design was used to compare the bioavailability of two brand name (A1 and A2) and one generic version (A3) of weight-reducing agents. Three sequences of administering the drugs were used in the study:

Sequence 1: A1, A2, A3

Sequence 2: A2, A3, A1

Sequence 3: A3, A1, A2 A random sample of five subjects was assigned to each of the three sequences. The AUCs for these 15 patients are shown here.

Question Continue In Page.

In Exercise 18.18

Many of us have been exposed to advertising related to the “bioavailability” of generic and brand- name formulations of the same drug product. One way to compare the bioavailability of two formulations of a drug product is to compare areas under the concentration curve (AUC) for subjects treated with both formulations. For example, the shaded area in the figure represents the AUC for a patient treated with a single dose of a drug.

A three- period crossover design was used to compare the bioavailability of two brand name (A1 and A2) and one generic version (A3) of weight-reducing agents. Three sequences of administering the drugs were used in the study:

Sequence 1: A1, A2, A3

Sequence 2: A2, A3, A1

Sequence 3: A3, A1, A2 A random sample of five subjects was assigned to each of the three sequences. The AUCs for these 15 patients are shown here.

Question Continue In Page.

## Answer to relevant Questions

An experiment is to be designed as a completely randomized design with a split-plot treatment assignment. Suppose the wholeplot treatment A has four levels. The split-plot treatments consist of the cross of two factors: ...Refer to Exercise 18.21. Using just the period 1 data, test for a difference in the fourformulations’ mean AUCs. Are your results consistent with the conclusions from Exercise 18.22? Why might the analysis of Exercise ...The following data are from Gennings, Chinchilli, and Carter, (1989). An in vitro toxicity study of isolated hepatocyte suspensions was conducted to study the impact of combining carbon tetrachloride (CCl4) and chloroform ...Refer to Exercise 18.36. In Exercise 18.36 Sodium nitrate, a preservative that is used in some processed meats, such as bacon, jerky, and luncheon meats, could increase your heart disease risk. A consumer protection ...Refer to the data in Exercise 18.7. In Exercise 18.7 The cayenne tick is recognized as a pest of wildlife, livestock, and humans. It is distributed in the Western Hemisphere between 308N and 30°S latitude. This tick has ...Post your question

0