Staphylococcus nuclease is an enzyme that catalyzes the hydrolysis of DNA. The overall hydrolysis reaction is as
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Recall that the nucleotides in DNA have phosphodiester linkages. The reaction is catalyzed by Ca2+, Glu 43, and Arg 87. Propose a mechanism for this reaction.
Transcribed Image Text:
RO-р —Он + RO-P-OR Н.о + ROH
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