Because of the position of arsenic in the periodic table, arsenate (AsO 4 3- ) is chemically

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Because of the position of arsenic in the periodic table, arsenate (AsO43-) is chemically similar to inorganic phosphate and is used by phosphate-requiring enzymes as an alternative substrate. Organic arsenates are quite unstable, however, and spontaneously hydrolyze. Arsenate is known to inhibit ATP production in glycolysis. Identify the target enzyme, and explain the mechanism of inhibition.

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Biochemistry Concepts And Connections

ISBN: 9780134641621

2nd Edition

Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews

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