Construct a table that lists all of the metabolic reactions from Chapters 12 and 13 that form or break C—C bonds. Arrange them according to whether the C—C bond is a or b to a carbonyl. Which reactions use thiamine pyrophosphate (TPP) as a cofactor? Explain the chemical basis of your observations.

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Reaction Aldolase Pyruvate decarboxylase Pyruvate carboxylase PEPCK 6-Phosphogluconate dehydrogenase Transketolase Transaldolase Pyruvate dehydrogenase Citrate synthase Isocitrate dehydrogenase a-Ketoglutarate dehydrogenase PEP carboxylase Malic enzyme Isocitrate lyase Malate synthase Is the bond aor ßto carbonyl? Use TPP?