Of the four DNA bases, why is guanine most likely to be modified after exposure to polycyclic

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Of the four DNA bases, why is guanine most likely to be modified after exposure to polycyclic hydrocarbons such as benzo(a)pyrene, as shown in Figure 23.8?

Figure 23.8.

Benzo(a)pyrene P450 HO HO NH BP 7,8-epoxide NH OH BPDE-deoxyguanosine adduct epoxide hydrolase DNA HO HO HO

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Biochemistry Concepts And Connections

ISBN: 9780134641621

2nd Edition

Authors: Dean Appling, Spencer Anthony-Cahill, Christopher Mathews

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Question Posted: Nov 06, 2023 10:34 AM

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Of the four DNA bases, why is guanine most likely to be modified after exposure to polycyclic

Question:

Benzo(a)pyrene P450 HO HO NH BP 7,8-epoxide NH OH BPDE-deoxyguanosine adduct epoxide hydrolase DNA HO HO HO BP 7,8-dihydrodiol P450 OH BP 7,8-dihydrodiol-9, 10-epoxide (BPDE)

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The reason guanine is most likely to be modified after exposure to polycyclic hydrocarbons such as benzoapyrene BP can be explained by the chemical st...View the full answer

Biochemistry Concepts And Connections

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