Given the Michaelis-Menten rate form to represent enzyme-substrate reactions (or catalyst-reactant reaction)

which of the following contacting patterns when operated properly gives good reactor behavior (close to minimum reactor size) and which will not, if the reactor is to be fed two feed streams, one containing C_A0, the other C_EO?

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A enzyme →→R, -TA KCACEO CA + (constant)