Gel-filtration chromatography separates molecules according to their size (Panel 44). Smaller molecules diffuse faster in solution than

Question:

Gel-filtration chromatography separates molecules according to their size (Panel 4−4). Smaller molecules diffuse faster in solution than larger ones, yet smaller molecules migrate more slowly through a gel filtration column than larger ones. Explain this paradox. What should happen at very rapid flow rates?

Panel 4−4