GPCRs activate G proteins by reducing the strength of GDP binding to the G protein. This results
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GPCRs activate G proteins by reducing the strength of GDP binding to the G protein. This results in rapid dissociation of bound GDP, which is then replaced by GTP, because GTP is present in the cytosol in much higher concentrations than GDP. What consequences would result from a mutation in the α subunit of a G protein that caused its affinity for GDP to be reduced without significantly changing its affinity for GTP? Compare the effects of this mutation with the effects of cholera toxin.
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A mutation in the subunit of a G protein that reduces its affinity for GDP without significantly changing its affinity for GTP would have similar cons...View the full answer
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Related Book For 
Essential Cell Biology
ISBN: 9780393680362
5th Edition
Authors: Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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