A pharmaceutical product is designed to be absorbed in the gastrointestinal tract. The active ingredient is pressed

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A pharmaceutical product is designed to be absorbed in the gastrointestinal tract. The active ingredient is pressed into a tablet with a density of p= 15 kg/m3 while the remainder of the tablet is composed of inactive ingredients. The partition coefficient is K = 3 X 10–2, and the diffusion coefficient of the active ingredient in the gastrointestinal fluid is DAB = 0.4 X 10–10 m2/s.

(a) Estimate the dosage delivered over a time period of 5 h for a spherical tablet of diameter D = 6 mm.

(b) Estimate the dosage delivered over 5 h for N = 200 small, spherical tablets contained in a gelatin capsule that quickly dissolves after ingestion, releasing the medication. The initial mass of the medication is the same as in part (a).

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Fundamentals Of Heat And Mass Transfer

ISBN: 9780470501979

7th Edition

Authors: Theodore L. Bergman, Adrienne S. Lavine, Frank P. Incropera, David P. DeWitt

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