The anti-inflammatory drug celecoxib, marketed as Celebrex, is widely used for treatment of rheumatoid arthritis. Draw a
Question:
The anti-inflammatory drug celecoxib, marketed as Celebrex, is widely used for treatment of rheumatoid arthritis. Draw a mechanism for the following step used in celecoxib synthesis.
Transcribed Image Text:
H₂N. لحة F3C Lo N مند NH2 CH3 F3C- N Celecoxib NH2 CH3 + 2H2O
Fantastic news! We've Found the answer you've been seeking!
Step by Step Answer:
Answer rating: 100% (4 reviews)
The given reaction is as follows The mechanism for the reaction is as follows The lone pair of elec...View the full answer
Answered By
User l_1013947
I possess a comprehensive understanding of programming languages such as C++, Python, HTML, CSS, and Jupyter Notebook. These technical skills enable me to develop robust software solutions and create visually appealing web pages. With my expertise in coding, I can effectively tackle complex programming tasks and deliver high-quality results.
0.00
0 Reviews
10+ Question Solved
Related Book For
Question Posted:
Students also viewed these Sciences questions
-
Celebrex, a drug manufactured by Pfizer, Inc., is used to relieve symptoms associated with osteoarthritis and rheumatoid arthritis in adults. In clinical trials of the medication, some subjects...
-
Morphine is a drug that is widely used for pain management. However, morphine can cause fatal respiratory arrest. Since pain perception and drug tolerance vary with patients, morphine is gradually...
-
How might a reductive amination be used to synthesize ephedrine, an amino alcohol that is widely used for the treatment of bronchialasthma? CHCHNHCH3 Ephedrine H3
-
In Exercises 1138, use the given conditions to write an equation for each line in point-slope form and slope-intercept form. Slope = -5, passing through (-4, -2)
-
SofTech, Inc., a developer and distributor of business applications software, has been in business for five years. SofTechs sales have increased steadily to the current level of $25 million per year....
-
Write a short Java method that takes an integer n and returns the sum of all the odd positive integers less than or equal to n.
-
A project has been selected for implementation. The net cash flow (NCF) profile associated with the project is shown below. MARR is 10 percent/year. a. What is the internal rate of return of this...
-
Juhn and Sons Wholesale Fruit Distributors (of Problem 13-19) are considering building a second platform or gate to speed the process of loading their fruit trucks. This, they think, will be even...
-
Ho: 5. Now let's consider the effects of comparing responses across samples. Suppose that groups 1 and 2 used the same people, and that responses for individuals 1 to 8 are listed in each row....
-
How might you prepare pentylamine from the following starting materials? (a) Pentanamide (b) Pentanenitrile (c) Pentanoic acid
-
How might you prepare each of the amines in Problem 12.32 from butan-1-ol? Problem 12.32 How might you prepare the following amines from 1-bromobutane? (a) Butylamine (b) Dibutyl amine (c) Pentylamine
-
Decide whether enough information is given to prove that the triangles are congruent using the SAS Congruence Postulate. AQRV, ATSU Q R V U S T
-
Which of the dependence measures discussed in the examples satisfy Axiom (i)? Justify the answers with proofs or counterexamples.
-
A patient sues a pharmacy for malpractice, alleging that a medication prescribed by a physician and dispensed by the pharmacy caused the patient harm. The attorney for the pharmacy made a motion for...
-
Bill is the pharmacy owner and PIC at Bills Pharmacy. The state Bills pharmacy is in has a freedom of choice law regarding third-party plans. You have been a long-time customer of Bills and you...
-
Using your state laws and rules, how does your state regulate LTCFs regarding pharmacies and/or pharmacists? Are these laws and regulations under the states pharmacy practice act or in another set of...
-
Billy is a pharmacist at Main Street Pharmacy and Sue the PIC. A routine inspection by a state pharmacy board inspector revealed that Billy had been refilling certain patients prescriptions without...
-
The term obligation is commonly used in federal government accounting. What is an obligation, and what is its equivalent in state and local government accounting?
-
Independent random samples of sizes n1 = 30 and n2 = 50 are taken from two normal populations having the means 1 = 78 and 2 = 75 and the variances 21 = 150 and 22 = 200. Use the results of Exercise...
-
When an acyl peroxide undergoes homolytic bond cleavage, the radicals produced can liberate carbon dioxide to form alkyl radicals: Using this information, provide a mechanism of formation for each of...
-
Identify which compounds below possess a molecular dipole moment and indicate the direction of that dipole moment: a. b. c. d. :i: i: .CI: II .C. .C. H. :: :Cl: . .C. .C. di: . CHO
-
A mixture of sulfuric acid and nitric acid will produce small quantities of the nitronium ion (NO2 + ): Does the nitronium ion have any significant resonance structures? Why or why not? o==o:
-
7. (10 points) The Wechsler Adult Intelligence Scale-Revised (WAIS-R) follows a Normal model with mean 100 and standard deviation 15. a. Draw and clearly label the model in order to use the Empirical...
-
How much money is needed to establish a fund paying $80,000 annually forever with the first payment made immediately if the fund will earn interest at 5% p.a. compounded semi-annually?
-
10. A security generates a fixed yet unknown cash flow of some amount for each of the first three years (i.e. t-1, t-2, and t-3), and then $1,000 per year for each of the remaining seven years (t-4...
Study smarter with the SolutionInn App