When the diethyl ester of a substituted malonic acid is treated with sodium ethoxide and urea, Veronal,
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When the diethyl ester of a substituted malonic acid is treated with sodium ethoxide and urea, Veronal, a barbiturate, is formed (see Fig. P22.84). (Barbiturates are hypnotic drugs; some are actively used in modern anes-thesia.) Using the curved-arrow notation, give a mechanism for the Veronal synthesis.
Transcribed Image Text:
O Et O _i_ || HN-C−NH, + EtOC—C−COEt Hi urea Et Figure P22.84 NaOEt EtOH H₂O+ Et Et IZ H NH Veronal (barbital) (a barbiturate)
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