Questions 5-8 refer to the following passage.

Given the information in the passage about blocking autoperfusion, which of the following could also be true?

a. DADLE and HIT must be present in an organ at the same time in order for autoperfusion to be prevented for any length of time.

b. If scientists could circumvent the passage of blood through the lymphatic system, organs would cease to deteriorate.

d. Scientists are close to developing a method to induce production of HIT in a non-hibernating animal.

d. Administering HIT after transplantation is likely to lower the current rates of infection and organ rejection.

e. Isolating and infusing opioids may be the key to retarding the progression of decay in transplant organs.

Transcribed Image Text:

Although multi-organ transplants have become more common, scientists and surgeons continue to face the ineluctable obstacle of time. Current Line donor organ preservation times hover around (5) five to six hours. Because of the complicated tissue-matching process, oftentimes organs are unable to reach their beneficiaries, wasting valuable, viable organs. However, scientists are hopeful that a certain substance, called the (10) Hibernation Induction Trigger (HIT), will extend the life of a potential transplant organ. HIT is an opiate-like substance found in the blood of hibernating animals. Previous experi- ments have shown that opioids act as an (15) autoperfusion block, preventing blood from flow- ing through the lymphatic system to organs, a phenomenon known as ischemia. In a preliminary experiment, an infusion of plasma with the Delta opioid delayed hemorrhaging in certain labora- (20) tory animals. When this arresting of activity was applied to the transplantation of organs, physi- cians reported preservation times up to 15 hours, a more than two-fold increase over standard conservation.