Inherited cancers like retinoblastoma show a dominant pattern of inheritance. However, the underlying genetic defect is a
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Inherited cancers like retinoblastoma show a dominant pattern of inheritance. However, the underlying genetic defect is a recessive loss-of-function mutation—often the result of a deletion. How can the dominant pattern of inheritance be reconciled with the recessive nature of the mutation?
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Principles of Genetics
ISBN: 978-1119142287
7th edition
Authors: D. Peter Snustad, Michael J. Simmons
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