Organocuprates predominantly react to give 1, 4-addition products with a, B-unsaturated carbonyl species, while Grignard reagents often
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Organocuprates predominantly react to give 1, 4-addition products with a, B-unsaturated carbonyl species, while Grignard reagents often add to the carbonyl. in a process referred to as 1, 2-addition. To increase the yield of 1, 4-addition products, Cul is added to convert an easily prepared Grignard reagent into a organocuprate reagent in situ (during the reaction). Predict the major product and stereochemistry of the following reaction, assuming that the more stable chair product predominates.
Related Book For
Elementary Principles of Chemical Processes
ISBN: 978-0471720638
3rd Edition
Authors: Richard M. Felder, Ronald W. Rousseau
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