A 10-year-old girl who is normally developed has chronic progressive exercise intolerance. On physical examination,temperature is...
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A 10-year-old girl who is normally developed has chronic progressive exercise intolerance. On physical examination,temperature is 37.1°C, pulse is 70/min, respirations are 14/min, and blood pressure is 100/60 mm Hg. A chest radiograph shows cardiomegaly and mild pulmonary edema. An echocardiogram shows severe left ventricular hypertrophy and a prominent interventricular septum. The right ventricle is slightly thickened. During systole, the anterior leaflet of the mitral valve moves into the outflow tract of the left ventricle. The ejection fraction is abnormally high, and the ventricular volume and cardiac output are both low. Which of the following is the most likely cause of the cardiac abnormalities in this patient? □(A) Mutations in ß-myos in heavy chain □ (B) Autoimmunity against myocardial fibers (C) Excessive iron accumulation (D) Deposition of amyloidprotein (E) Latent enterovirus infection A 10-year-old girl who is normally developed has chronic progressive exercise intolerance. On physical examination,temperature is 37.1°C, pulse is 70/min, respirations are 14/min, and blood pressure is 100/60 mm Hg. A chest radiograph shows cardiomegaly and mild pulmonary edema. An echocardiogram shows severe left ventricular hypertrophy and a prominent interventricular septum. The right ventricle is slightly thickened. During systole, the anterior leaflet of the mitral valve moves into the outflow tract of the left ventricle. The ejection fraction is abnormally high, and the ventricular volume and cardiac output are both low. Which of the following is the most likely cause of the cardiac abnormalities in this patient? □(A) Mutations in ß-myos in heavy chain □ (B) Autoimmunity against myocardial fibers (C) Excessive iron accumulation (D) Deposition of amyloidprotein (E) Latent enterovirus infection
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Applied Regression Analysis and Other Multivariable Methods
ISBN: 978-1285051086
5th edition
Authors: David G. Kleinbaum, Lawrence L. Kupper, Azhar Nizam, Eli S. Rosenberg
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