A 57-year-old woman with a history of hypertension and arthritis is referred to a rheumatologist for...

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A 57-year-old woman with a history of hypertension and arthritis is referred to a rheumatologist for evaluation. A complete blood count (CBC) is normal, and a mini-chem panel shows no electrolyte abnormalities. Her erythrocyte sedimentation rate (ESR) is elevated, and an antinuclear antibody test (ANA) is positive. Further antibody studies are performed, and the results are shown below. Anti-histones high titer Anti-double stranded DNA not detected Anti-single stranded DNA not detected Anti-SSA not detected not detected Anti-SSB Anti-SCI-70 Anti-Smith not detected not detected Anit-centromere Anti-RNP not detected not detected Which of the following diseases is suggested by these results? A. CREST syndrome B. Diffuse form of scleroderma C. Drug-induced lupus D. Sjögren's syndrome E. Systemic lupus erythematosus A 57-year-old woman with a history of hypertension and arthritis is referred to a rheumatologist for evaluation. A complete blood count (CBC) is normal, and a mini-chem panel shows no electrolyte abnormalities. Her erythrocyte sedimentation rate (ESR) is elevated, and an antinuclear antibody test (ANA) is positive. Further antibody studies are performed, and the results are shown below. Anti-histones high titer Anti-double stranded DNA not detected Anti-single stranded DNA not detected Anti-SSA not detected not detected Anti-SSB Anti-SCI-70 Anti-Smith not detected not detected Anit-centromere Anti-RNP not detected not detected Which of the following diseases is suggested by these results? A. CREST syndrome B. Diffuse form of scleroderma C. Drug-induced lupus D. Sjögren's syndrome E. Systemic lupus erythematosus

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