a) Using 3D representations, rationalize why the deprotonation of ketone (18) with LDA gives the trans-configured enolate
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Question:
a) Using 3D representations, rationalize why the deprotonation of ketone (18) with LDA gives the trans-configured enolate (19).
b) Using your knowledge of Felkin-Anh control, rationalize why compound (21) has an anti stereochemical relationship between C2 and C3.
c) Using 3D representations, invoke a Zimmer-Traxler structure to account for why compound (21) has the syn stereochemical relationship between C1 and C2.
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