BPG binds to hemoglobin and thereby affects hemoglobins ability to bind oxygen. Each beta subunit contributes 3
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Question:
- BPG binds to hemoglobin and thereby affects hemoglobin’s ability to bind oxygen.
- Each beta subunit contributes 3 residues that bind BPG: His2, Lys82, and His143. How is it possible for all three of these residues, distant in the amino acid sequence, to bind BPG?
- BPG and His143 interact in Hemoglobin’s central cavity. What’s the strongest type of interaction possible between His and BPG: ________________ and between HHis+ and BPG:________________. Which of these BPG interactions (with His or HHis+) is stronger?
- If His143 has the standard pKa for a free Histidine (see table on page 1), what is the probability that His143 will be protonated at blood pH of 7.4? Show your work for full credit.
- What His143 pKa value would give ≥90% of His143 in the protonated state at pH 7.4? Justify your answer/show your work.
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Understanding financial statements
ISBN: 978-0136086246
9th Edition
Authors: Lyn M. Fraser, Aileen Ormiston
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