Before performing NCL, the two peptide fragments of barstar must first of all be synthesised using...
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Before performing NCL, the two peptide fragments of barstar must first of all be synthesised using SPPS. Provide a general reaction scheme that details how one of the peptide fragments could be synthesised. Your answer should include the following information: (i) The type of resin used. (ii) The protecting group used for the protection of the alpha-amino group; the rationale for why it was selected, and the conditions used for its removal. (iii) The coupling reagent(s) utilised. (iv) The reaction conditions employed for release of the target peptide from the resin and effecting global deprotection. Before performing NCL, the two peptide fragments of barstar must first of all be synthesised using SPPS. Provide a general reaction scheme that details how one of the peptide fragments could be synthesised. Your answer should include the following information: (i) The type of resin used. (ii) The protecting group used for the protection of the alpha-amino group; the rationale for why it was selected, and the conditions used for its removal. (iii) The coupling reagent(s) utilised. (iv) The reaction conditions employed for release of the target peptide from the resin and effecting global deprotection.
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