In the lungs, oxygen diffuses from the gas phase to blood across the alveolar membrane. Since...
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In the lungs, oxygen diffuses from the gas phase to blood across the alveolar membrane. Since the thickness of this membrane is very small (0.20 microns), it behaves like a thin aqueous layer for O₂ transport. The partial pressure of O₂ (P02) is 104 mmHg in alveolar air and 40 mmHg in venous blood (the blood that arrives to the lungs). The partial pressure and concentration of O₂ can be related using Henry's law, namely [0₂] =]] Po2, where is the solubility coefficient, [₂] is expressed in mL O₂ per mL water at STPD, and P02 , is in atmospheres. At 37°C, = 0.024 and the O₂ diffusion coefficient in water is 1.5x105 cm² s¹. R = 0.0821 L atm mol¹ K-¹, and 1 atm = 760 mmHg. Standard temperature and pressure in dry air are 0°C and 1 atm. A. Determine the effective permeability of the alveolar membrane to O₂. You may assume that the partition coefficient of O₂ between air and water is 1. B. Determine the flux of O₂ from an alveolus to the pulmonary capillaries, assuming that the partial pressure of O₂ in lung capillaries is everywhere equal to venous P02. Give your answer in mL O₂ cm°² s¹¹. C. If 70 L O₂ are transported across all alveoli into the blood per minute, what is the surface area of the lungs (in m²)? In the lungs, oxygen diffuses from the gas phase to blood across the alveolar membrane. Since the thickness of this membrane is very small (0.20 microns), it behaves like a thin aqueous layer for O₂ transport. The partial pressure of O₂ (P02) is 104 mmHg in alveolar air and 40 mmHg in venous blood (the blood that arrives to the lungs). The partial pressure and concentration of O₂ can be related using Henry's law, namely [0₂] =]] Po2, where is the solubility coefficient, [₂] is expressed in mL O₂ per mL water at STPD, and P02 , is in atmospheres. At 37°C, = 0.024 and the O₂ diffusion coefficient in water is 1.5x105 cm² s¹. R = 0.0821 L atm mol¹ K-¹, and 1 atm = 760 mmHg. Standard temperature and pressure in dry air are 0°C and 1 atm. A. Determine the effective permeability of the alveolar membrane to O₂. You may assume that the partition coefficient of O₂ between air and water is 1. B. Determine the flux of O₂ from an alveolus to the pulmonary capillaries, assuming that the partial pressure of O₂ in lung capillaries is everywhere equal to venous P02. Give your answer in mL O₂ cm°² s¹¹. C. If 70 L O₂ are transported across all alveoli into the blood per minute, what is the surface area of the lungs (in m²)?
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Part A The effective permeability of the alveolar membrane to O can be determined using the followin... View the full answer
Related Book For
Fundamentals Of Momentum Heat And Mass Transfer
ISBN: 9781118947463
6th Edition
Authors: James Welty, Gregory L. Rorrer, David G. Foster
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