Problem 2: According to the New England Journal of Medicine 2020 the clinical trial evaluating the...
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Problem 2: According to the New England Journal of Medicine 2020 the clinical trial evaluating the efficacy and safety of the BNT162b2 (Pfizer COVID-19 Vaccine) has shown mixed results in terms of adverse events over the course of a 3 month assessment period. Data is present in the table below with person's either being given a placebo or the BNT162b2 vaccine candidate. Adverse events are reported as positive (having had Adverse Events) or Negative (not having BNT162b2 Placebo Total Adverse Event Positive 5,865 (a) 2,607 (c) 8,472 (a + c) Adverse Event Negative 15,855 (b) 19,121 (d) 34,976 (b + c) Total 21,720 (a + b) 21,728 (c + d) 43,448 (a+b+c+d) 2. What is the Odds Ratio for the prevalence of adverse effects given vaccine administration compared to placebo. 3. Provide the interpretation of the Odds Ratio 4. Manually compute the Relative Risk for the prevalence of adverse effects given vaccine administration compared to placebo. 5. Provide the interpretation of the Relative Risk 6. Compute and interpret the PAR for adverse effects attributed to the vaccine administration. (Round to three decimal places) 7. Provide an interpretation for the PAR for adverse effects attributed to the vaccine administration. Problem 2: According to the New England Journal of Medicine 2020 the clinical trial evaluating the efficacy and safety of the BNT162b2 (Pfizer COVID-19 Vaccine) has shown mixed results in terms of adverse events over the course of a 3 month assessment period. Data is present in the table below with person's either being given a placebo or the BNT162b2 vaccine candidate. Adverse events are reported as positive (having had Adverse Events) or Negative (not having BNT162b2 Placebo Total Adverse Event Positive 5,865 (a) 2,607 (c) 8,472 (a + c) Adverse Event Negative 15,855 (b) 19,121 (d) 34,976 (b + c) Total 21,720 (a + b) 21,728 (c + d) 43,448 (a+b+c+d) 2. What is the Odds Ratio for the prevalence of adverse effects given vaccine administration compared to placebo. 3. Provide the interpretation of the Odds Ratio 4. Manually compute the Relative Risk for the prevalence of adverse effects given vaccine administration compared to placebo. 5. Provide the interpretation of the Relative Risk 6. Compute and interpret the PAR for adverse effects attributed to the vaccine administration. (Round to three decimal places) 7. Provide an interpretation for the PAR for adverse effects attributed to the vaccine administration.
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