Rationalise the following observations using valence-bond structures for the possible intermediates. Pyridine undergoes electrophilic substitution only with
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Rationalise the following observations using valence-bond structures for the possible intermediates.
Pyridine undergoes electrophilic substitution only with difficulty and predominantly in the 3-position, while pyridine N-oxide undergoes electrophilic substitution very easily and predominantly at the 2- and 4-positions. (8 marks)
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