Reactions in complex II. Use of FAD instead of NAD + in the oxidation of succinate. All
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Reactions in complex II. Use of FAD instead of NAD + in the oxidation of succinate. All dehydrogenases from glycolysis and the citric acid cycle use NAD + (E ′ ° for NAD + / NADH is −0.32V) as the electron acceptor, except succinate dehydrogenase, which uses covalently linked FAD (E ′ ° for FAD / FADH2 in this enzyme is 0.050 V). Suggest why FAD is a more appropriate electron acceptor than NAD + in the dehydrogenation of succinate, based on the E ′ ° values of:
fumarate / succinate (E ′ ° = 0.031 V),
NAD + / NADH (E ′ ° = −0.32V)
succinate dehydrogenase FAD / FADH2 (E ′ ° = 0.050 V)
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