What are the mechanisms underlying chromosome segregation errors during cell division, including spindle assembly checkpoint signaling, kinetochore-microtubule attachments, and chromosome cohesion dynamics, and how do these errors lead to aneuploidy and chromosomal instability in cancer and developmental disorders? 

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Chromosome segregation errors during cell division can result from various mechanisms including issues with spindle assembly checkpoint SAC signaling kinetochoremicrotubule attachments and chromosome ... View the full answer