4- and 5-hydroxy acids can undergo acid-catalyzed intramolecular esterification to produce the corresponding lactone in good yield.
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4- and 5-hydroxy acids can undergo acid-catalyzed intramolecular esterification to produce the corresponding lactone in good yield. Consider the following two examples of lactonization. Divide the analysis of the reaction sequences among your group. Propose reasonable mechanisms to explain the respective product formation.
Reconvene to present your mechanisms to each other.
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Related Book For
Organic Chemistry structure and function
ISBN: 978-1429204941
6th edition
Authors: K. Peter C. Vollhardt, Neil E. Schore
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