Tablet hardness is one comparative measure for different formulations of the same drug product; some combinations of ingredients (in addition to the active drug) in a formulation give rise to harder tablets than do other combinations. Suppose that three batches of a formulation are randomly selected for examination. Three different 1-kg samples of tablets are randomly ­selected from each batch, and seven tablets are randomly selected for testing from each of the 1-kg samples. The hardness readings are given here.
a. Identify the design.
b. Give an appropriate model with assumptions.
c. Give the sources of variability and degrees of freedom for an AOV.
d. Perform an analysis of variance, and draw conclusions about the tablet hardness data for the formulation under study. Use α = .05.

  • CreatedNovember 21, 2015
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