The catalytic behavior of liver and brain phosphofructokinase-1 (PFK-1) was observed in the presence of AMP, Pi, and fructose- 2,6-bisphosphate. The following table lists the concentrations of each effector required to achieve 50% of the maximal velocity. Compare the response of the two isozymes to the three effectors and discuss the possible implications of their different responses.

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PFK-1 isozyme Liver Brain Pl 200 μΜ 350 μΜ AMP 10μΜ 75 μΜ [F2,6P] 0.05 μΜ 4,5 μΜ