The first step in the biological degradation of lysine is reductive amination with ?-ketoglutarate to give saccharopine.

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The first step in the biological degradation of lysine is reductive amination with ?-ketoglutarate to give saccharopine. Nicotinamide adenine dinucleotide phosphate (NADPH), a relative of NADH, is the reducing agent. Show the mechanism.

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Organic Chemistry

ISBN: 9780495112587

7 Edition

Authors: John McMurry

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Question Posted: Mar 08, 2011 05:48 AM

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The first step in the biological degradation of lysine is reductive amination with ?-ketoglutarate to give saccharopine.

Question:

H NH3 Co H2N NADPH/H+ NADP+ Lysine H NH3 "02с н 02C 'N' CO2 Saccharopine Co a-Ketoglutarate

Step by Step Answer:

00 0 0C HN CO O CO H2O Nucleophilic ad...View the full answer

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