The SHP-2 protein participates in insulin signaling through its indirect activation by the insulin receptor (Fig. 13-31),
Question:
In Figure 13.31
Transcribed Image Text:
Insulin Raf Ras Sos CAP IR Shc APS/Cbl pY TC1O pY pY 3 Gab-1 IRS proteins py SHP 2 PY PI3K Lipid rafts MEK SHR-2 py pY Fyn PDK1 MAPK MTORPKB/Akt РКСС PKca Jun Myc p9osk S6 kinase Fos AS160 S6 DNA/RNA/Protein synthesis Glycogen synthesis Glucose transport Cellular growth and differentiation Metabolism
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Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
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