There are many methods for activating a carboxylic acid in preparation for coupling with an amine. The
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(a) Explain why an NHS ester is much more reactive than a simple alkyl ester.
(b) Propose a mechanism for the reaction shown.
(c) Propose a mechanism for the reaction of the NHS ester with an amine, R - NH2.
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a One important factor in ester reactivity is the ability of the alkoxy group to leave and ...View the full answer
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