What is the metabolic advantage of having both hexokinase and glucokinase to phosphorylate glucose?
Answer to relevant QuestionsWhat is the effect on gluconeogenesis and glycogen synthesis of (a) Increasing the level of ATP, (b) Decreasing the concentration of fructose-1,6-bisphosphate, and (c) Increasing the concentration of fructose-6-phosphate? Why is it advantageous for two control mechanisms —allosteric control and covalent modification—to be involved in the metabolism of glycogen? Explain how the pentose phosphate pathway can respond to a cell’s need for ATP, NADPH, and ribose-5- phosphate. What are the major differences between the oxidations in the citric acid cycle that use NAD+ as an electron acceptor and the one that uses FAD? NADH is an important coenzyme in catabolic processes, whereas NADPH appears in anabolic processes. Explain how an exchange of the two can be effected.
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