A. How many different DNA fragments would you expect to obtain if you cleaved human genomic DNA

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A. How many different DNA fragments would you expect to obtain if you cleaved human genomic DNA with HaeIII? How many fragments would you expect with EcoRI?

B. Human genomic libraries used for DNA sequencing are often made from fragments obtained by cleaving human DNA with HaeIII in such a way that the DNA is only partially digested; that is, not all the possible HaeIII sites have been cleaved. What is a possible reason for doing this?

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Essential Cell Biology

ISBN: 9780393680362

5th Edition

Authors: Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff, Keith Roberts, Peter Walter

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