As described in Chapter 15, the methylation of cytosine bases can have an important effect on gene expression. For example, the methylation of cytosines may inhibit the transcription of genes. A methylated cytosine base has the following structure:

Would you expect the methylation of cytosine to affect the hydrogen bonding between cytosine and guanine in a DNA double helix? Why or why not? Take a look at solved problem S3 and speculate as to how methylation could affect gene expression.

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