1. For each pair of twins, compute the following for the lumbar spine: A = BMD for...

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1. For each pair of twins, compute the following for the lumbar spine:

A = BMD for the heavier-smoking twin − BMD for the lighter-smoking twin = x1 − x2

B = mean BMD for the twinship = (x1 + x2)/2

C = 100% × (A/B)

Derive appropriate descriptive statistics for C over the entire study population. 

2. Suppose we group the twin pairs according to the difference in tobacco use expressed in 10 pack-year groups (0–9.9 pack-years/10–19.9 pack-years/20–29.9 pack-years/30–39.9 pack-years/40+ pack-years). Compute appropriate descriptive statistics, and provide a scatter plot for C grouped by the difference in tobacco use in pack-years?

3. What impression do you have of the relationship between BMD and tobacco use based on Problem 2? 

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