What procedure can be used to test the hypothesis that there has been no mean difference in

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What procedure can be used to test the hypothesis that there has been no mean difference in IOP after 60 days Data set available between the two drug regimens? 


Ophthalmology

A study was performed among patients with glaucoma, an important eye disease usually manifested by high intraocular pressure (IOP); left untreated, glaucoma can lead to blindness.


The patients were currently on two medications (A and B) to be taken together for this condition. The purpose of this study was to determine whether the patients could drop medications A and B and be switched to a third medication (medication C) without much change in their IOP. Ten patients were enrolled in the study. They received medications A + B for 60 days and had their IOP measured at the end of the 60-day period (referred to as IOPA+B). They were then taken off medications A and B and switched to medication C, which they took for an additional 60 days. IOP was measured a second time at the end of the 60-day period while the patient was on medication C (referred to as IOPC). The results were as shown in Table 7.12.

Table 7.12: Effect of medication regimen on IOP among glaucoma patients

 IOP (mm Hg) Patient number IOP, (mm Hg) 1 18.0 14.5 16.0 18.0 3 17.0 11.5 4 18.0 18.0 20.0 21.0 19.0 22.0 24.0 19.0 12.0

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